The Composition of Collagen-Containing Preparations from Rhopilema asamushi Uchida Jellyfish and Assessment of the Safety of their External Use

The researchers developed methods for obtaining polyfunctional preparations of various degree of purification from rhopilema jellyfish in the form of collagen and proteoglycane complexes, and assessed their safety for the external applications. The safety of external use of the obtained preparations was analyzed in test animals in terms of acute toxicity, as well as skin irritation and sensitizing effects in accordance with the requirements for the toxicological characteristics of ingredients of cosmetics.